骨组织工程中壳聚糖支架材料的设计与改性

Research progress on design and modification of chitosan scaffolds in bone tissue engineering

因外伤、肿瘤、组织感染坏死等多种原因造成的骨组织缺损无法或无法完全自行修复,需要良好的骨组织替代物帮助修复,因此学者们一直致力于研发与改性各种骨再生支架材料以更好地帮助修复骨缺损。壳聚糖因具有良好的生物可降解性、生物相容性等被视为骨组织工程支架材料绝佳原料。本文仅对近年来骨组织缺损修复与再生中学者们对壳聚糖支架材料改性设计与改性方法进行简要综述。

Bone defect caused by trauma,post-surgery tumor or septic necrosis usually cannot or cannot be completely restored by itself,and needs suitable substitute bones to help repair the defect. Thus scientists have been making efforts in developing and optimizing all sorts of scaffolds for bone tissue engineering. Chitosan has been served as one of the excellent raw materials of scaffolds for its outstanding biodegradability and biocompatibility. This paper focuses on reviewing recent studies on design and modification of chitosan scaffolds in restoration of bone defect and regeneration.