股骨头坏死患者血清白细胞介素-33和C-反应蛋白水平及其临床意义

The levels of serum interleukin-33 and C-reactive protein in patients with osteonecrosis of femoral head and its clinical significance

目的探讨股骨头坏死患者血清白细胞介素-33(IL-33)、C-反应蛋白(CRP)水平及其临床意义。方法选择股骨头坏死患者72例为观察组,其中早期(Ⅰ~Ⅱ期)27例、晚期(Ⅲ~Ⅳ期)45例;同期选择健康者81例为对照组。测定两组血清IL-33、CRP水平,并分析观察组血清IL-33与CRP水平之间的相关性。结果观察组患者血清IL-33、CRP水平高于对照组(P<0.05),临床FicatⅢ~Ⅳ期患者血清IL-33、CRP水平高于FicatⅠ~Ⅱ期患者(P<0.05);观察组患者血清IL-33与CRP水平呈正相关(P<0.05)。结论股骨头坏死患者血清IL-33、CRP水平变化能够反映病情变化,有助于股骨头坏死的预后判断。

Objective To investigate the levels and clinical significance of interleukin-33（ IL-33） and C-reactive protein（ CRP）in patients with osteonecrosis of femoral head（ ONFH）. Methods A total of 72 cases with ONFH,including 27 cases of early stage（ stageⅠ to Ⅱ） and 45 cases of advanced stage（ stage Ⅲ to Ⅳ）,were selected as the observation group,and 81 cases of healthy persons were enrolled as control group. The serum levels of IL-33 and CRP were measured in all the subjects,and their correlation were analyzed.Results The serum levels of IL-33 and CRP in the observation group were higher than that of the control group,respectively（ P 〈0. 05）,and both were higher in advanced stage than in early stage（ P 〈0. 05）. The serum IL-33 level was positively correlated with CRP levelin the observation group（ P 〈0. 05）. Conclusion The serum levels of IL-33 and CRP can reflect the disease condition in ONFH patients,which is helpful to estimate the prognosis of it.