九味消疡汤对比尼扎替丁片治疗十二指肠溃疡患者脾胃湿热证临床疗效及安全性

Efficacy and safety of Jiuwei Xiaoyang soup vs nizatidine tablets in treatment of duodenal ulcer patients with spleen-stomach dampness-heat syndrome

目的探讨九味消疡汤对比尼扎替丁片治疗十二指肠溃疡患者脾胃湿热证临床疗效及对相关安全性分析.方法临床选取2015-01/2016-05入浙江中医药大学附属第一医院治疗的十二指肠溃疡脾胃湿热证患者80例.随机抽取40例患者使用九味消疡汤进行治疗,将其作为实验组;将另外的40例患者使用尼扎替丁片进行治疗,将其作为对照组.对2组患者治疗6 wk的疗程.观察比较患者在治疗前后的临床症状改善率,溃疡复发率以及胃镜下的改善率.观察并比较幽门螺杆菌(Helicobacter pylori,H.pylori)的清除率.从而客观评价九味消疡汤的疗效.结果使用九味消疡汤进行治疗的患者的临床改善率显著高于使用尼扎替丁片进行治疗的患者,实验组的对患者口干口苦、身重肢倦等一些临床表现的改善显著高于对照组,且2组数据差异具有统计学意义(P<0.05);在溃疡复发率的改善上,在对2组患者的随访过程中发现,实验组的复发率显著低于对照组,数据差异具有统计学意义(P<0.05).在胃镜下的溃疡面积改善率方面,使用九味消疡汤与使用尼扎替丁片的疗效并无太大差异,2组数据差异无统计学意义(P>0.05).在H.p y l o r i感染的清除方面,使用九味消疡汤治疗的疗效明显优于使用尼扎替丁片,且差异具有统计学意义(P<0.05).结论九味消疡汤对比尼扎替丁片治疗十二指肠溃疡患者脾胃湿热证临床疗效更为显著.九味消疡汤能够改善十二指肠溃疡患者脾胃湿热证临床症状,对降低溃疡的复发率作用显著.

AIM To compare the efficacy and safety of Jiuwei Xiaoyang soup and nizatidine tablets in the treatment of duodenal ulcer patients with spleen-stomach dampness-heat syndrome.METHODS Eighty duodenal ulcer patients with spleenstomach dampness-heat syndrome treated from January 2015 to May 2016 were randomly divided into either an experimental group to receive Jiuwei Xiaoyang soup（n = 40） or a control group to receive nizatidine tablets（n = 40）. The treatment lasted six weeks in both groups. The rates of clinical improvement, gastroscopic improvement, and recurrence were compared between the two groups.RESULTS The rate of clinical improvement（e.g., dry mouth and body weight） was significantly higher in the experimental group than in the control group（P 〈 0.05）. The rate of ulcer recurrence was significantly lower in the experimental group than the control group（P 〈 0.05）. The rate of gastroscopic improvement did not differ significantly between the two groups（P 〉 0.05）.CONCLUSION Jiuwei Xiaoyang soup is superior to nizatidine tablets in improving clinical symptoms andreducing ulcer recurrence in duodenal ulcer patients with spleen-stomach dampness-heat syndrome.