2656例男性原发不育患者的细胞遗传学分析

Chromosome analysis of 2656 cases of male patients with primary sterility

目的探讨男性原发不育与染色体异常的关系。方法对来自广东省计划生育专科医院不育门诊的2656例男性原发不育患者进行染色体核型分析。结果在这2656例男性患者中,共检出异常核型417例,染色体异常发生率为15.70%(417/2656)。其中性染色体数目异常339例,占总异常的81.29%(339/417),性染色体结构异常28例,占6.71%(28/417),常染色体数目异常2例,占0.48%(2/417),常染色体结构异常44例,占10.55%(44/417)。对染色体异常患者进行精液常规分析。结论染色体异常是造成男性原发不育的重要遗传因素,染色体检查对男性原发不育患者的诊断与治疗有重要意义。

Objective：To investigate the relationship between chromosomal abnormalities and male primary sterility. Methods：Chromosome analysis was performed in 2656 male patients with primary sterility from Family Planning Special Hospital of Gangdong. Results：417 cases of chromosomal abnormalities were checked out from 2656 total cases and the abnormal rate was 15.70%. The number of abnormal sex chromosomes number is 339 cases,accounting for 81.29% of the total abnormal chromosomes,the number of abnormal sex chromosomes structure is 28 cases,accounting for 6.71%,the number of abnormal euchromosomes number is 2 cases,accounting for 0.48%,the number of abnormal euchromosomes structure is 44 cases,accounting for 10.55%. The routine semen analysis was performed in patients with abnormal chromosome. Conclution：The chromosomal anomalies are important inheritance factor for male primary sterility. Chromosome analysis was very important for diagnosis and treatment of male patients with primary sterility.