892例男性不育患者外周血染色体异常核型分析

Analysis of chromosome Karyotype among infertile males patients from 2011 to 2015

目的对不育男性患者进行外周血染色体核型的分析,探讨染色体异常与男性不育的遗传学效应。方法按常规方法制作染色体标本,G显带,400条带水平进行不育男性患者染色体核型分析。结果受检的892例患者中,检查出染色体异常核型88例,异常检出率为9.87%。包括性染色体异常67例和常染色体异常21例,分别占受检不育男性患者的7.51%和2.35%。在所有染色体异常核型中,Klinefelter综合征的发生率最高,有24例,占异常核型的27.27%。结论染色体异常是导致男性不育的重要原因之一,染色体核型分析对不育男性患者的诊断和治疗具有重要的指导意义。

Objectives：To analyze the karyotypes of infertile male patients so as to investigate the relationship between male infertility and chromosome abnormalities. Methods：The chromosome karyotypes of 892 male infertile patients were analyzed by routinely cultured peripheral blood lymphocytes. Results：There were 88 cases of abnormal karyotypes which accounted for 9.87%,including 67（7.51%）cases of sex abnormal karyotype and 21（2.35%）cases of autosome abnormal karyotype. The Klinefelter syndrome was the most common disease caused by abnormal karyotype and the ratio was 27.27% in all the abnormal karyotypes. Conclusion：Chromosome abnormality is an important cause of male infertility. Karyotype analysis is important for the diagnosis and treatment of male infertility.