ω-3多不饱和脂肪酸对脂代谢与骨代谢的影响

Effects of ω-3 polyunsaturated fatty acids on fat metabolism and bone metabolism

肥胖与骨质疏松是临床上常见的代谢性疾病，肥胖患者体内氧化应激、炎症介质、细胞因子水平的改变对骨代谢有一定影响。ω-3多不饱和脂肪酸除作为能量来源外，还可调节细胞信号传导，调控基因的表达，进而影响脂代谢与骨代谢。本文综述了肥胖与骨质疏松之间的联系，并从流行病学、动物实验学及分子机制方面归纳了ω-3多不饱和脂肪酸在脂代谢与骨代谢中的作用。

There are mounting evidences demonstrating that obesity and osteoporosis pose a daunting threat on global public health problem, given their morbidity and mortality. ω-3 polyunsaturated fatty acids , besides as a source of energy, may regulate the cellular signal transduction pathway to produce specific patterns of gene expression, and protect from complications of obesity and osteoporosis. This article reviewed the correlation between obesity and osteoporosis, and summarized the effects and potential mechanism of ω-3 polyunsaturated fatty acids on fat metabolism and bone metabolism from both animal experiments and epidemiological studies.