5-HTTLPR基因多态性与原发性早泄关系研究进展

Research on relations between primary premature ejaculation and serotonin transporter promoter gene polymorphism

早泄(PE)是一种常见的男性性功能障碍,目前的研究尚未能揭示所有PE患者的病因,因此进一步阐明PE发病机制以改善PE治疗思路具有重要意义。近年的研究热点显示PE还受遗传因素的影响,PE发病与基因多态性之间的相关性受到了重视,并主要集中在5-羟色胺(5-HT)相关基因研究上。本文旨在综述原发性PE相关5-HT转运体基因启动子区(5-HTTLPR)基因多态性方面的发病机制的研究进展。

Premature ejaculation（ PE） is a common male sexual dysfunction,the cause of which remains mostly unclear. It is therefore of significant importance to further explain the mechanism of the disorder as well as widen the scope of therapy ideas through more in- depth research. Recent research has shown that the onset PE may be influenced by hereditary factors,and there is a significant relationship between onset of the disorder and gene polymorphism,more specifically,genes related to the production and management of 5- hydroxytryptamine（ 5-HT）. This article aims to provide an overview of the research and development on primary premature ejaculation in relations to serotonin transporter promoter gene polymorphism and its onset mechanism.