摘要
目的:探讨双侧基底节筛孔状态的MRI表现及可能的临床意义。方法:选取63例双侧基底节筛孔状态患者作为病例组,并通过MRI评价其病灶形态、信号特点;同时选取63例性别、年龄相匹配的正常志愿者作为对照组,病例组及对照组均进行中文版简易智能状态检查量表(MMSE)评分;并按性别分层,研究高血压与双侧基底节筛孔状态的关系。结果:所有病灶集中于双侧壳核、豆状核,且呈双侧对称性、筛孔状分布;病灶在T_2WI上呈高信号,T_1WI及FLAIR T_2WI上呈低信号,无明确壁或胶质增生表现,扩散未见明确受限表现。病例组的MMSE总评分[(26.00±1.95)分]较对照组[(28.44±1.15)分]低,且两者间差异具有统计学意义(Z=-7.15,P<0.001)。分层χ2检验结果提示两性高血压与筛孔状态均存在相关性(χ_M^2=19.19,P_M<0.001;χ_F^2=13.60,P_F=0.001)。结论:双侧基底节筛孔状态是一种病理改变,与患者认知功能损伤有一定关系,高血压可能是其中一个危险因素,应引起临床重视。
Objective:To investigate the MRI features of cribriform state in the basal ganglia and correlations with cognitive impairment.Methods:Imaging archive of 63 patients with cribriform state was reviewed.All patients underwent the brain MR examination.Lesions were evaluated by size and signal intensity.All the patients with cribriform state and 63age-and gender-matched controls underwent mini-mental state examination(MMSE).Besides,the correlation between hypertension and cribriform state was evaluated with Mantel-Haenszel statistic.Results:T2-weighted MRI shows bilateral innumerable high-intensity spots in both putamen and caudate nucleus.There were no signs of acute infarct on DWI.The MMSE scores of cribriform state group and control group were(26.00±1.95)and(28.44±1.15),respectively.The difference of the MMSE scores between two group was statistically significant(Z=-7.15,P〈0.001).Significant correlation existed between hypertension and cribriform state(χM^2=19.19,PM 0.001;χF^2=13.60,PF=0.001).Conclusion:Cribriform state is always abnormal,it may correlate with cognitive impairment in the elderly people.Hypertension may be one of the risk factors of cribriform state.
出处
《放射学实践》
北大核心
2017年第2期122-125,共4页
Radiologic Practice
基金
国家自然科学基金资助(81471654)
关键词
神经节
基底
筛孔状态
磁共振成像
简易智能状态检查量表
认知障碍
Ganglia
basal
Cribriform state
Magnetic resonance imaging
Mini-mental state examination
Cognition disorders