摘要
目的探讨富马酸喹硫平片与碳酸锂联合用药方案治疗双相情感障碍躁狂发作的临床效果。方法选择2014年9月~2016年3月收治的双相情感障碍躁狂患者142例作为研究对象,将所有患者随机分为对照组与治疗组,两组分别有71例患者,对照组应用碳酸锂治疗,治疗组应用富马酸喹硫平片联合碳酸锂治疗,比较两组患者临床疗效。结果治疗组患者治疗后的BRMS、PANSS以及CPT评分均要显著优于对照组与治疗前(P<0.05);治疗组临床总有效率是91.5%,对照组临床总有效率是76.1%,两组患者临床治疗效果对比具有显著性差异(P<0.05);治疗组不良反应发生率是14.1%,对照组不良反应发生率是22.5%,组间不良反应发生情况对比无显著性差异(P>0.05)。结论双相情感障碍躁狂发作患者应用富马酸喹硫平片与碳酸锂联合用药方案治疗具有显著疗效,能够明显改善患者临床症状与部分认知功能,不良反应少,值得临床大力推广应用。
Objective To investigate the clinical effect of quetiapine fumarate tablets combined with lithium carbonate in the treatment of manic episode of bipolar affective disorder,and to provide reference for clinical rational drug use. Methods A total of 142 cases with manic episode of bipolar affective disorder in Shenyang Mental Health Center from September 2014 to March 2016 were selected as the study subjects,these patients were randomly divided into the control group and the treatment group,71 cases in each group. the control group was treated with lithium carbonate,and the treatment group used Quetiapine Fumarate Tablets combined with lithium carbonate in the treatment; the clinical efficacy of the two groups were compared. Results after treatment,the BRMS,PANSS and CPT scores of the treatment group were significantly better than the control group and prior treatment( P〈0. 05); The clinical total effective rate of the treatment group and the control group were 91. 5% and 76. 1% respectively,and there was significant difference between the two groups( P〈0. 05); the incidence of adverse reactions in the treatment group and control group were14. 1% and 22. 5% respectively,and there was no significant difference between the two groups( P〉0. 05). Conclusions quetiapine fumarate tablets combined with lithium carbonate in the treatment of manic episode of bipolar affective disorder has significant effect,can significantly improve cognitive function in part and clinical symptoms,with slight adverse reactions,it is worth clinical popularizing and applying.
出处
《航空航天医学杂志》
2017年第1期57-60,共4页
Journal of Aerospace medicine
关键词
富马酸喹硫平片
碳酸锂
双相情感障碍
躁狂发作
Quetiapine Fumarate Tablets
Lithium Carbonate
Manic Episode
Bipolar Affective Disorder