急性脑梗死患者血清尿酸、超敏C反应蛋白水平变化及临床意义

Changes of Serum Uric Acid and High-sensitive C-reactive Protein in Patients with Acute Cerebral Infarction and Its Clinical Significance

目的探讨急性脑梗死患者血清尿酸、超敏C反应蛋白水平变化以及临床意义。方法选择2013年1月~2015年12月神经内科收治的102例ACI患者作为研究观察组,再选择同期健康体检者42名作为研究对照组,通过运用尿酸酶比色法与免疫散射比浊法检测两组受检者的血清UA与hs-CRP水平,运用NIHSS评分评估ACI患者神经功能缺损程度并比较不同程度神经缺损患者的血清UA与hs-CRP水平。结果观察组患者的血清UA与hs-CRP水平要显著高于对照组(P<0.05);中度神经缺损患者与重度神经缺损患者的血清UA与hsCRP水平要明显高于轻度神经缺损患者(P<0.05),重度神经缺损患者的血清UA与hs-CRP水平要明显高于中度神经缺损患者(P<0.05)。结论急性脑梗死患者的血清尿酸与超敏C反应蛋白水平明显上升;且血清尿酸与超敏C反应蛋白水平与急性脑梗死病情严重程度呈正相关;血清尿酸与超敏C反应蛋白可以作为临床防治脑梗死的辅助观测指标。

Objective To investigate the changes of serum uric acid（ UA） and high- sensitive C- reactive protein（ hs- CRP） in patients with acute cerebral infarction（ ACI） and its clinical significance. Methods A total of 102 cases with ACI were treated in Central Hospital of Liaoyang during period from January 2013 to December 2015,these patients were chosen for this study as the observation group,and then select 42 health people during the same period in our hospital to receive a medical examination as the control group. urate oxidase colorimetric method and immune scatter turbidity method was used to detect serum UA and hs- CRP levels of subjects in the two groups,National Institute of Health stroke scale（ NIHSS） score was used to evaluate the degree of neurological deficits in patients with ACI and to compare the serum levels of UA and hs- CRP in patients with different degree of neurological impairment. Results The serum levels of UA and hs- CRP in the observation group were significantly higher than those in the control group（ P〈0. 05）; serum UA and hs CRP levels in patients with moderate nerve defect and patients with severe neurological deficit was significantly higher than that patients with mild neurological defect（ P〈0. 05）; serum UA and hs- CRP levels in patients with severe neurological deficits were significantly higher than those in patients with moderate impairment of nerve（ P〈0. 05）. Conclusions In patients with ACI,serum UA and hs- CRP levels increased significantly; there is a positive correlation between the severity of ACI and the serum UA and hs- CRP. serum UA and hs- CRP can be used as an auxiliary indicator for clinical treatment and prevention of ACI.