胃肠道间质瘤的免疫组织化学及病理特证

Immunohistochemical and pathological features of gastrointestinal stromal tumors

目的:探讨胃肠间质瘤免疫组织化学及病理特证。方法:选取30例手术切除并经免疫组织化学及病理证实为胃肠间质瘤患者的病理标本,对其进行S-100、SMA、CD34和CD117等免疫组织化学分析。结果:27例患者的胃肠间质瘤标本CD117表达阳性,阳性表达率为90.0%;21例CD34表达阳性,阳性率为70.0%,CD34阳性表达率低于CD117,且有统计学意义(P<0.05)。结论:胃肠间质瘤为胃肠道常见的间叶性肿瘤,缺乏定向分化,CD34和CD117为其标记物。

Objective： To investigate immunohistochemical and pathological features of gastrointestinal stromal tumors. Methods： The pathological specimens from 30 immunohistochemically and pathologically confirmed gastrointestinal stromal tumor patients and undergone the resection surgeries were selected,and the S-100,SMA,CD34 and CD117 features were analyzed by the immunohistochemical staining. Results： In 27 cases,CD117 expression was positive with a positive rate of 90.0%. In 21 cases,CD34 expression was positive with the positive rate of 70.0%. The positive expression rate of CD34 was lower than that of CD117,and the difference was statistically significant（ P〈0.05）. Conclusions： The gastrointestinal stromal tumor is a common gastrointestinal mesenchymal tumor and poorly oriented-differentiated,and CD34 and CD117 are its markers.