托拉塞米联合甘露醇治疗脑出血脑水肿疗效分析

To Observe the Curative Effect of Torasemide Combined with Mannitol in Treatment of Brain Edema in Cerebral Hemorrhage

目的探讨托拉塞米联合甘露醇治疗脑出血脑水肿的临床疗效。方法方便选取2014年2月—2015年3月该院收治的脑出血脑水肿患者104例,随机分成两组,每组52例,一组为对照组给予患者甘露醇进行治疗,并行常规抗感染、控制血压等治疗手段;另一组为观察组,采用在对照组的基础上联合应用托拉塞米进行治疗,观察两组治疗效果、神经功能缺损评分情况,并进行分析。结果观察组有效率为88.46%,对照组为61.54%,观察组的治疗总有效率明显高于对照组,两组间差异有统计学意义(P<0.05)。两组患者治疗前后神经缺损评分的比较均有明显的下降(P<0.05),两组患者在治疗前评分差异无统计学意义(P>0.05),治疗后评分观察组明显比对照组低(P<0.05),治疗前后及治疗后组间差异有统计学意义。观察组不良反应发生率为1.92%,对照组不良反应发生率为5.77%,观察组不良反应发生率与对照组不良反应发生率对比差异无统计学意义(P>0.05)。结论托拉塞米联合甘露醇治疗脑出血脑水肿的临床疗效显著,治疗后患者的神经损伤恢复得更好,并且能在一定程度上减少不良反应的发生,值得临床上予以广泛使用。

Objective To investigate the clinical curative effect of torasemide combined with mannitol in treatment of cerebral hemorrhage and edema.Methods Convenient selection February 2014 to March 2015 in our hospital 104 cases of cerebral edema and cerebral hemorrhage were randomly divided into two groups, 52 cases in each group, a group of patients for the control group were given mannitol treatment, parallel conventional anti-infective control blood pressure treatment; another group of the observation group, the use of the control group based on the combination of torasemide treatment, therapeutic effects were observed, neurological deficit scores, and to analyze. Results The effective rate of observation group was88.46%, the control group was 61.54%, the total effective rate of the observation group was significantly higher than that of the control group（P〈0.05）, and the difference between the two groups was statistically significant.Scores of nerve defect before and after the treatment, the patients in the two groups had significantly decreased（P〈0.05）, the two groups of patients before treatment scores had no significant difference（P〈0.05）. After treatment, the score in the observation group significantly than that of the control group（P〈0.05）, the difference between the two groups before and after treatment and after treatment have statistical significance. The incidence of adverse reactions in the observation group was 1.92%. In the control group, the incidence rate of adverse reaction was 5.77%, observation group the incidence of adverse reactions and the control group, the incidence rate of adverse reaction without significant difference（P〈0.05）. Conclusion The clinical curative effect of torasemide combined with mannitol in treatment of cerebral hemorrhage and edema significantly,After treatment,patients with nerve injury recovered better, and can reduce the incidence of adverse reactions to a certain extent, it is worth to be widely used in clinical practice.