呼出气一氧化氮检测在咳嗽变异性哮喘中的诊断意义

Diagnosis Significance of Expiratory Air of Nitric Oxide Test in the Cough Variant Asthma

目的评估呼出气一氧化氮(FeNO)检测在咳嗽变异性哮喘(CVA)诊断中的临床应用价值。方法整群选取2015年1—12月于深圳市第二人民医院呼吸科就诊的慢性咳嗽病例,其中确诊CVA 83例,非CVA 166例,两组进行FeNO检测,比较两组的FeNO值,分析FeNO诊断CVA的最佳界值。结果 CVA组的FeNO值为(55.11±33.09)ppb(1ppb=1×10-9mo L/L)显著高于其他病因慢性咳嗽组的(21.85±10.51)ppb,差异有统计学意义(P<0.01),应用FeNO从慢性咳嗽中诊断哮喘的ROC曲线下面积为0.894,最佳界值为31.5 ppb,以该界值诊断CVA的灵敏度为84.3%,特异度为88.0%,准确度为72.3%。结论 FeNO测定对CVA的诊断具有较高的灵敏度和特异度。

Objective To evaluate the clinical application value of expiratory air of nitric oxide test in the cough variant asthma. Methods Group selection the cases with chronic cough diagnosed in the department of respiration in Shenzhen Second People＇s Hospital from January 2015 to December 2015 were selected, and 83 cases were diagnosed with CVA, and166 cases were diagnosed with non-CVA, and the FeNO value of the two groups was compared, and the best cutoff points of CAV diagnosed by FeNO was analyzed. Results The FeNO value in the CVA group was obviously higher than that in the cause group, [（55.11±33.09） ppb vs（21.85±10.51）ppb],（1ppb=1×10-9mo L/L）, and the difference had statistical significance（P0.01）, and the ROC roc curve area under curve diagnosed by FeNO was 0.894, and the best cutoff value was 31.5 ppb,and the sensitivity, specificity and accuracy of CVA diagnosed by the cutoff value were respectively 84.3%, 88.0% and72.3%. Conclusion The sensitivity and specificity of FeNO in diagnosis of CVA are higher.