血浆同型半胱氨酸水平与慢性阻塞性肺疾病相关性的研究

Research on Correlation between the Blood Plasma Homocysteine Level and Chronic Obstructive Pulmonary Diseases

目的分析血浆同型半胱氨酸(Hcy)的检测在慢性阻塞性肺疾病COPD诊断中的临床价值。方法整群收集2015年6月—2016年6月该科室收治的COPD患者病例168例作为观察组,同期在医院体检者157名作为对照组。分别比较两组病例血浆Hcy浓度、两组患者中吸烟患者及未吸烟者血浆Hcy浓度及观察组COPD不同分级患者的入院及出院Hcy浓度。结果经比较,观察组血浆Hcy浓度(28.18±4.35)μmol/L明显低于对照组血浆Hcy浓度(14.33±3.05)μmol/L,差异有统计学意义(P<0.05)。COPDⅠ级患者出院时Hcy浓度为(12.77±1.53)μmol/L,Ⅱ级为(16.21±2.12)μmol/L,Ⅲ级为(20.71±3.46)μmol/L,Ⅳ级为(22.42±4.52)μmol/L,与入院时Hcy浓度相比,均有所下降(P<0.05),血浆Hcy浓度随患者病情的加深而升高(P<0.05)。结论血浆Hcy浓度与COPD的病情发展呈正相关,对于临床诊断COPD具有一定指导意义。

Objective To analyze the clinical value of Hcy test in the diagnosis of COPD. Methods Group selection 168 cases of patients with COPD admitted in our department from June 2015 to June 2016 were selected as the observation group, and 157 cases of patients with physical examination at the same period were selected as the control group, and the blood plasma Hcy concentration of the two groups was compared, and the admission and discharge Hcy concentration of the two groups was compared. Results The comparison showed that the plasma Hcy concentration in the observation group was obviously lower than that in the control group,（28.18±4.35）μmol/L vs（14.33±3.05）μmol/L, and the difference had statistical significance（P0.05）, and the Hcy concentration at discharge of patients with COPDⅠ level, Ⅱlevel, Ⅲ level and Ⅳ level was respectively（12.77±1.53）μmol/L,（16.21±2.12）μmol/L,（20.71±3.46）μmol/L and（22.42±4.52）μmol/L, and all decreased compared with that at admission（P0.05）, and with the deepening of patient＇s condition, the blood plasma Hcy concentration increased（P0.05）. Conclusion The blood plasma Hcy concentration is positively correlated with the development of COPD, which is of a certain guidance significance to the clinical diagnosis of COPD.