1Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010 [J]. CA Cancer J Clin, 2010, 60(5) : 277 -300.
2Wolpin B M, Mayer R J. Systemic treatment of colorectal cancer[J]. Gastroenterology, 2008, 134 ( 5 ) : 1296 - 1310.
3Holness M J, Sugden M C. Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation [ J ]. Biochem Soc Trans, 2003, 31(Pt 6) : 1143 - 1151.
4Roche T E, Hiromasa Y. Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer[J]. Cell Mol Life Sci, 2007, 64(7/8) : 830 -849.
5Rustum Y M. Clinical implications of 5-FU modulation [ J ]. Oncology (Williston Park), 1999, 13(7 Suppl 3) : 22 -25.
6Catenacci D V, Kozloff M, Kindler H L, et al. Personalized colon cancer care in 2010[J]. Semin oncol, 2011, 38(2) : 284-308.
7Chen Y, Cairns R, Papandreou I, et al. Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect [J]. PLoS One, 2009, 4(9) : e7033.
8Sheng H, Niu B, Sun H. Metabolic targeting of cancers : from molecular mechanisms to therapeutic strategies [ J ]. Curr Med Chem, 2009, 16(13) : 1561 -1587.
9Michelakis E D, Webster L, Mackey J R. Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer [ J ]. Br J Cancer, 2008 , 99(7) : 989 -994.
10Wong J Y, Huggins G S, Debidda M, et al. Dichloroacetate induces apoptosis in endometrial cancer cells[ J ]. Gynecol Oncol, 2008, 109 (3) : 394 - 402.
