转运蛋白NupC与NupG微生物胞内核苷分泌的作用研究进展

Research Progresses on the Role of Transport Proteins NupC and NupG During the Nucleoside Secretion Processing in Microbial Cells

核苷用途广泛,微生物发酵法是其主要的生产方法之一。微生物细胞内核苷的分泌对于高产核苷有重要的作用,其细胞膜上存在多种起运输作用的转运蛋白参与代谢产物的分泌。主要阐述核苷转运蛋白NupC和NupG在微生物细胞内核苷分泌过程中的作用。此外,介绍了转运蛋白的修饰改造对于核苷生物合成的影响,旨在为构建高产菌株的育种策略提供依据。

The nucleosides are used extensively, and microbial fermentation is one of main methods of producing it. The secretion of nucleoside in microbial cells plays a critical role for high-yield nucleoside. There are many transport proteins as the role of transportation in the cell membrane, which are involved in the secretion of metabolites. Here, this article mainly elaborates the role of nucleoside transport proteins such as NupG and NupC during the uucleoside secretion process in microbial cells. Additionally, the effects of modification for transport protein on nucleoside biosynthesis were introduced, aiming at providing evidence for the breeding strategy of engineering high-yield strains.