片形吸虫排泄分泌产物的研究进展

Research Advances in Excretory-secretory Products of Fasciolaspp.

片形吸虫病(fascioliasis)是由片形吸虫(Fasciolaspp.)感染而引起的一种人兽共患寄生虫病,能引起动物"大批死亡",是影响全球公共卫生和畜牧业经济发展的重要问题。片形吸虫在与宿主长期互作过程中,产生抵抗宿主免疫应答的方法得以在宿主体内保存下来,而片形吸虫生长发育的各个时期的排泄分泌产物(excretory-secretory products,ESP)在其中发挥了重要作用,ESP按功能大致分为氧化应激相关蛋白、能量代谢相关蛋白和蛋白酶体相关蛋白三类。在片形吸虫的免疫逃避中,ESP也发挥了重要作用。因此本文中笔者对其进行综述,旨在为研制新型疫苗或药物提供参考。

Fascioliasis is a sort of zoonotic disease caused by Fasciolaspp.,which can cause a large number of deaths in animals.It is considered to be a major problem for effecting on global public health and husbandry economic development.The method of resistance of host immune response that can survive in the host during the process of long-term mutual struggle between Fasciola spp.and its host.However,the excretory-secretory products（ESP）in different developmental stages of Fasciolaspp.play a significant role in this process.In fact,ESP can be divided into oxidative stress related proteins,proteins related to energy metabolism and the proteasome associated proteins according to the functions.The ESP play important roles in the immune evasion of the Fasciolaspp.Therefore,this dissertation expounded its functions with the purpose of providing implications for the research of new vaccines or drugs.