活心方加载对冠心病心绞痛患者动脉粥样硬化的影响

Effects of“Huoxin prescription”on atherosclerosis in patients with angina pectoris of coronary heart disease

目的以心踝血管指数(cardio-ankle vascular index,CAVI)、踝臂指数(ankle-brachial index,ABI)、颈动脉内中膜厚度(intima-media thickness,IMT)及脉压(pulse pressure,PP)为观测指标,研究活心方对冠心病心绞痛患者动脉粥样硬化的影响。方法入选58例符合中医气虚血瘀证的冠心病心绞痛患者随机分为中药加载组(30例)和常规治疗组(28例),所有入选患者均采用西药常规治疗,中药加载组患者在西药常规治疗的基础上加用活心方,疗程3个月。分别于治疗前、治疗后检测两组患者的CAVI、ABI、IMT及PP,并进行统计分析。结果经治疗后,中药加载组CAVI、IMT降低,与治疗前及与常规治疗组相比有统计学意义(P<0.05);中药加载组PP降低,与治疗前相比有统计学意义(P<0.05),但与常规治疗组相比无统计学意义(P>0.05);中药加载组ABI升高,但与治疗前及与常规治疗组相比无统计学意义(P>0.05)。结论活心方能有效改善动脉粥样硬化,但不能明确对ABI的影响。

Objective To study the effects of＂Huoxin prescription＂on atherosclerosis in patients with angina pectoris of coronary heart disease by using the observation index of cardio-ankle vascular index（ CAVI）,ankle-brachial index（ ABI）,intima-media thickness（ IMT） and pulse pressure（ PP）. Methods 58 patients of angina pectoris of Coronary heart disease with Qi deficiency and blood stasis syndrome were randomly assigned into traditional Chinese medicine（ TCM） group（ 30 cases） and conventional treatment group（ 28 cases）. All the patients involved were treated with conventional western medicine,and the patients in TCM group were given the Chinese medicine,Huoxin prescription,in addition. The medication was administered for three months.Before and after treatment,CAVI,ABI,IMT and PP were detected and the statistical analysis was performed respectively in two groups. Results After treatment,CAVI and IMT of the patients in TCM group were decreased,compared with before treatment and conventional treatment group had statistical significance（ P 〈 0. 05）; PP of the patients in TCM group was decreased,compared with before treatment had statistical significance（ P 〈 0. 05）,but compared with conventional treatment group had no statistical significance（ P 〉 0. 05）. ABI of the patients in TCM group was increased,but compared with before treatment and conventional treatment group had no statistical significance（ P 〉 0. 05）. Conclusion ＂Huoxin prescription＂can effectively relieves atherosclerosis,but it can not be clear about the effect of ABI.