中医药防治颈动脉粥样硬化的作用机制研究进展

The research progress mechanism of TCM prevention and treatment of carotid artery atherosclerosis

中医药具有多组分、多途径、多层次和多靶点的作用特点,在防治颈动脉粥样硬化的发生和发展中的作用机制主要涉及到抑制炎性反应,稳定易损斑块;降低氧化应激反应,保护血管内皮功能,抑制血管平滑肌细胞增殖;抑制血管壁的微血管新生,增加斑块稳定性;上调VEGF的表达,促进血管内皮细胞修复与新生;减少基质金属蛋白酶表达,抑制斑块增殖和破溃等,延缓动脉粥样硬化病变的发展,抑制斑块内出血、溃疡及斑块脱落,减少心脑血管病事件的发生。

The traditional Chinese medicine have multicomponent,multi-channel,multi-level and multiple targets function characteristics,the mechanism of occurrence and development in the prevention and treatment of carotid artery atherosclerosis mainly involves inhibiting inflammatory reaction,stable vulnerable plaque. Reduce oxidative stress,protecting endothelial function,inhibiting vascular smooth muscle cell proliferation. Inhibit blood vessel walls of capillaries,increase the plaque stability.Increase the expression of VEGF and promote restoration of the vascular endothelial cells and newborn. Reduce the expression of matrix metalloproteinases,restrain plaque proliferation and burst,delay the development of atherosclerotic lesions,inhibition of intraplaque neovasculature,ulcers and peeling plaques,reducing the occurrence of cardio-cerebrovascular disease events.