安胎复方中药的毒性实验研究

Experimental Study on the Toxicity of Traditional Chinese Medicine Tocolysis Compound

目的:评价老中医所用安胎中药复方的急性毒性和长期喂药对小鼠肝脏、肾与卵巢、输卵管、子宫的慢性毒性。方法:对小鼠按照急性和长期毒性实验方法灌胃复方汤药,观察各个实验周期内的大鼠、小鼠的毒性反应和死亡情况。结果:检测各小鼠给药处理组,计算此安胎中药复方的最大耐受量为40g/kg。中等剂量给药,对小鼠肝脏、肾脏和生殖系统未见明显影响,按正常剂量给药,没有表现毒性。结论:此安胎中药复方在临床常用剂量时安全,有开发应用前景。

Objective： To evaluate the acute toxicity of traditional Chinese medicine tocolysis compound toxins and the chronic toxicity of long - term administration to mice liver, kidney and ovary, fallopian tube and uterus. Methods： Toxicity and death were observed in mice and mice by intragastric administration of compound decoction in accordance with the acute and long -term toxicity test in mice. Results： The maximum tolerated dose of this compound was 40 g / kg. Moderate dose administration, the mouse liver, kidney and reproductive system had no significant effect, no toxicity was observed according to the normal dose administration. Conclusions： This kind of traditional Chinese medicine compound prescription is safe and has the prospect of development and application in clinical common dose.