非小细胞肺癌转移相关的细胞因子研究进展

Advances in Cytokines of Non-small Cell Lung Cancer Metastasis

肺癌是临床最常见的恶性肿瘤之一,严重危害着人类健康。研究发现多种细胞因子参与肺癌细胞的基膜降解、血管生成及免疫逃逸过程,对肺癌的发生、发展及转移起着重要作用。本文就与非小细胞肺癌的侵袭和转移密切相关的几种细胞因子进行综述。

Lung cancer is one of the most common clinical malignant tumor, and it causes serious damages to hu- man health. It has been confirmed that a variety of cytokines involved in tumor cells of basement membrane degra- dation, angiogenesis and immunal escaping procession, which plays an important role on the occurrence, development and transfer of lung cancer. In order to understand the mechanisms of interaction of lung cancer with cytokines, domestic and foreign scholars carried on a series of thorough researches. In this paper, the relationship between several kinds of cytokines and lung cancer, especiaUy the relationship with non - small cell lung cancer were reviewed on invasion and metastasis.