1Fingar DC,Blenis J.Target of rapamycin(TOR):An integrator ofnutrient and growth factor signals and coordinator of cell growthand cell cycle progression.Oncogene 2004;23(18):3151-71.
2Laplante M,Sabatini DM.mTOR signaling at a glance.J CellSci 2009;122(20):3589-94.
3Sarbassov DD,Guertin DA,Ali SM,Sabatini DM.Phosphor tionand regulation of Akt/PKB by the rictor-mT0R complex.Science2005;307(5712):1098-101.
4Asnaghi L,Bruno P,Priuna M,Nicolin A.mTOR:A proteinkinase switching between life and death.Pharmcol Res 2004;50(6):545-9.
5Foster KG,Fingar DC.mTOR:Conducting the cellular signalingsymphony.J Biol Chem 2010;285(19):14071-7.
6Ma J,Meng Y,Kwiatkowski DJ,Chen X,Peng H,Sun Q,et al.Mammalian target of rapamycin regulatesmurine and human celldifferentiation through.STAT3/p63/Jagged/Notch cascade.J ClinInvest 2010;120(1):103-14.
7Deutsch MA,Kaczmarek I,Huber S,Schmauss D,Beiras-Fernandez A,Schmoeckel M,et al.Sirolimus-associated infertil-ity:Case and literature review of possible mechanisms.Am JTransplant 2007;7(10):2414-21.
8Skizypek J,Krause W.Azoospermia in a renal transplantrecipient during sirolimus(rapamycin)treatment.Andrologia2007;39(5):98-9.
9Huyghe E,Zairi A,Nohra J,Kamar N,Plante P,Rostaing L.Gonadal impact of target of rapamycin inhibitors(sirolimus andeverolimus)in male patients:An overview.Transpl Int 2007;20(4):305-11.
10Kaczmarek I,Groetzner J,Adamidis I,Landwehr P,Mueller M,Vogeser M,et al.Sirolimus impairs gonadal function in hearttransplant recipients.Am J Transplant 2004;4(7):1084-8.
