Short-duration transient visual evoked potentials and color reflectivity discretization analysis in glaucoma patients and suspects

AIM: To evaluate the use of short-duration transient visual evoked potentials(VEP) and color reflectivity discretization analysis(CORDA) in glaucomatous eyes,eyes suspected of having glaucoma,and healthy eyes.METHODS: The study included 136 eyes from 136 subjects: 49 eyes with glaucoma,45 glaucoma suspect eyes,and 42 healthy eyes.Subjects underwent Humphrey visual field(VF) testing,VEP testing,as well as peripapillary retinal nerve fiber layer optical coherence tomography imaging studies with post-acquisition CORDA applied.Statistical analysis was performed using means and ranges,ANOVA,post-hoc comparisons using Turkey's adjustment,Fisher's Exact test,area under the curve,and Spearman correlation coefficients.RESULTS: Parameters from VEP and CORDA correlated significantly with VF mean deviation(MD)(P<0.05).In distinguishing glaucomatous eyes from controls,VEP demonstrated area under the curve(AUC) values of 0.64-0.75 for amplitude and 0.67-0.81 for latency.The CORDA HR1 parameter was highly discriminative for glaucomatous eyes vs controls(AUC=0.94).CONCLUSION: Significant correlations are found between MD and parameters of short-duration transient VEP and CORDA,diagnostic modalities which warrant further consideration in identifying glaucoma characteristics.