邻香草醛缩4-氯邻氨基苯酚Schiff碱正丁基锡配合物的合成、晶体结构及生物活性研究

Synthesis,Crystal Structure and Biological Activity of the Schiff Base Dibutyltin Complex Based on o-Vanillin and 4-Chloro-2-Aminophenol

利用邻香草醛缩4-氯邻氨基苯酚Schiff碱(H2L)和正丁基三氯化锡反应,合成了一个Schiff碱正丁基锡配合物(C1),通过元素分析、FT-IR、~1H NMR、^(13)C NMR以及X-射线单晶衍射对合成的有机锡Schiff碱配合物C1进行了表征。研究了配合物(C1)的紫外可见光谱,并且运用MTT方法,研究了该有机锡Schiff碱配合物对癌细胞的体外抑制活性,研究的结果显示,该有机锡Schiff碱配合物C1对MCF7、NCI-H460的抑制活性相比卡铂要更优越,因而可以考虑经过化学优化后,作为抗癌药物的备选化合物。

Schiff base organotin（IV） complex C1 has been synthesized via the reaction of the o-vanillin-4-chloride-2-aminophenol Schiff base （H2 L） with the butyhin trichloride.The complex has been characterized by IR, 1H NMR,13C NMR spectra, elemental analysis and X-ray diffraction.The UV-vis spectra of the complex was determined.The anticancer activity of the Schiff base ligand （H2L） and complex C1 against five species of cancer ceil which are Hela, MCF7, HepG2, Colo205, NCI-H460 were tested respectively,and the tests showed that the complex was more active than carboplatin against tested MCF7, NCI-H460 cancer cell lines and has a potential application of drug preparation.