前列地尔联合瑞舒伐他汀对高血压早期肾损害尿微量白蛋白的影响

Effect of alprostadil combined with rosuvastatin on early renal damage in essential hypertension microalbuminuria

目的探讨前列地尔联合瑞舒伐他汀对早期高血压肾损害尿微量白蛋白的影响。方法选择高血压早期肾损害患者120例,随机分为A组、B组和C组,所有患者均予缬沙坦治疗,A组为对照组,B组加用前列地尔,C组加用前列地尔和瑞舒伐他汀。三组患者连续治疗2周。采用放射免疫分析法检测治疗前后尿α1微球蛋白(α1-MG)、尿转铁蛋白(TRF)和尿微量白蛋白(MA)。结果三组治疗后两两比较尿α1微球蛋白(α1-MG)、尿转铁蛋白(TRF)和尿微量白蛋白(MA)水平显著降低,差异有统计学意义(P均<0.05)。结论三组均能降低高血压早期肾损害尿微量蛋白尿,但C组前列地尔和瑞舒伐他汀联合应用,比其他两组降低尿微量白蛋白疗效更明显。

Objective To investigate the effect of alprostadil combined with rosuvastatin on early renal damage in essential hypertension microalbuminuria .Methods Hypertension and early renal damage in patients with 120 cases randomly divided into group A , group B and group C , all patients were given valsartan treatment , group A as the control group , group B with alprostadil and group C with alprostadil and rosuvastatin .Three groups of patients received treatment for two weeks .The urine α1 microglobulin （α1-MG）, urinary transferrin （TRF） and microalbuminuria （ MA） were detected by radioimmunoassay .Results In the three groups , the levels of α1-MG, urinary TRF and MA were significantly decreased after treatment , and the difference was statistically significant （ P〈0.05） .Conclusions Hypertension early renal damage of MG have decreased in three groups , but alprostadil combined with rosuvastatin applied in group C can have more obvious effect than the other two groups in reducing microalbuminuria .