221例急性百草枯中毒患者临床病死率相关数据分析

Data analysis related to the mortality of 221 cases of patients with acute paraquat poisoning

目的:通过分析急性百草枯中毒患者的临床资料为判断预后提供依据。方法:收集221例急性百草枯口服中毒患者的年龄、性别、服毒剂量、就诊时间、入院72h内受累器官与病死率的关系进行回顾性分析。结果:1女性患者人数明显高于男性患者,年龄主要集中在中青年。2将服毒剂量分组比较,各组患者入院72h内监测到首发受损器官中肾脏损害的比例最高(P<0.01)。随服毒剂量增大,72h内损害脏器数量与病死率不断递增,当服毒剂量>100ml时,72h内损害器官数量超过3个的该组患者已高达36.0%,病死率达到88.0%,显著高于其他各组(P<0.01)。3小剂量服毒患者(<5ml)均预后良好,与就诊时间无明显相关性。服毒剂量>50ml,就诊时间超过24h的患者病死率为100%。结论:急性百草枯中毒患者以中青年女性居多。服毒剂量、就诊时间、早期损伤器官数量与患者病死率密切相关。

Objective：To provide evidences for clinical prognosis by analyzing the data related to the mortality of patients with acute paraquat poisoning.Method：Clinical data of 221paraquat-poisoned patients admitted into the emergency department was recorded,including the age,gender,toxic dose,admission time and affected organs within 72 hours.Result：1The number of female patients is significantly higher than male patients,mainly in young and middle-aged.2Kidney damage was the highest percentage of first-damaged organs in the patients admitted to hospital within 72hours（P〈0.01）.With the increase of toxic dose,an increasing rate was observed about the number of damaged organs within 72 hours and the mortality.When the toxic dose was larger than 100 ml,the percentage of patients,who had more than three damaged-organs within 72 hours,was as high as 36.0%,and the mortality was 88.0%,significantly higher than other groups（P〈0.01）.3Patients taken small toxic dose（〈5 ml）have good prognosis,which was independent of the admission time.The mortality of patients,who arrived at the hospital after 24 hours taken larger than 50 ml paraquat,was 100%.Conclusion：The majority of patients with acute paraquat poisoning were young and middle-aged women.The mortality of patients with acute paraquat poisoning have close ties to the toxic dose,admission time and affected organs within 72 hours.