口腔卫生状况与舌癌发病关系的病例对照研究

Association between Oral Hygiene and Tongue Cancer (A Case-Control Study)

目的探讨口腔卫生状况对舌癌发病的影响。方法采用病例对照的研究方法,病例组为2010年12月-2015年12月经病理学确诊的舌癌新发病例243例,对照组为社区来源的、经年龄及性别频数匹配的1 046例健康者。采用单因素和多因素的非条件Logistic回归模型计算OR值及其95%CI,评估口腔卫生状况对舌癌发病的影响。结果牙齿缺失（目前牙齿数为20-27颗和〈20颗）、口腔不良修复体、复发性口腔溃疡可显著增加舌癌的发病风险,其调整的OR分别为1.78（95%CI：1.24-2.55）,3.02（95%CI：1.93-4.73）,1.95（95%CI：1.41-2.70）,4.17（95%CI：2.49-6.99）;刷牙频率（1次/天和≥2次/天）、口腔保健周期（2-4年/次和≤1年/次）可降低舌癌的发病风险,其调整的OR分别为0.26（95%CI：0.14-0.49）,0.14（95%CI：0.07-0.26）,0.45（95%CI：0.25-0.82）,0.37（95%CI：0.17-0.79）。结论口腔卫生状况对舌癌的发病有一定影响,增加刷牙频率和口腔保健次数,改善不良的口腔卫生状况可在一定程度上减少舌癌的发生。

Objective To evaluate the association between oral hygiene and tongue cancer.Methods A case-control study including 243 patients with pathologically confirmed tongue cancer and1046 controls with frequency matched by age and gender were performed in Fujian province from December2010 to December 2015. Univariate and multivariate logistic regression was used to calculate odds ratio（OR）and corresponding 95% confidence interval（CI）between oral hygiene and tongue cancer. Results Tooth loss（the number of teeth were 20-27and〈20）,bad prosthesis and repetitive oral ulcer significantly increased the risk of tongue cancer,the corresponding OR were 1.78（95%CI：1.24-2.55）,3.02（95%CI：1.93-4.73）,1.95（95%CI：1.41-2.70）,4.17（95%CI：2.49-6.99）,respectively. On the contrary,tooth brushing frequency（1time/day and≥2times/day）,oral health care（2-4years/times and ≤1year/time）were associated with decreased risk of tongue cancer,the corresponding OR were0.26（95%CI：0.14-0.49）,0.14（95%CI：0.07-0.26）,0.45（95%CI：0.25-0.82）,0.37（95%CI：0.17-0.79）. Conclusions Oral hygiene has an effect on the incidence of tongue cancer. Increase in frequency of tooth brushing and oral health care,and improving the poor oral hygiene can reduce the risk of tongue cancer to a certain extent.