连续性静-静脉血液滤过对急性重症胰腺炎患者外周血IL-6、PCT及CRP的影响

The Influence of Peripheral Blood IL-6, PCT and CRP of the Patients With Severe Acute Pancreatitis by Continuous Venovenous Hemofiltration

目的探讨给予急性重症胰腺炎(Severe Acute Pancreatitis,SAP)患者连续性静-静脉血液滤过(Continuous venovenous hemofiltration,CVVH)对其外周血IL-6、PCT及CRP影响。方法选取在我院就诊的SAP患者60例,随机分为两组,各30例。对照组行常规治疗,观察组行CVVH治疗,对比分析两组临床疗效、IL-6、PCT及CRP水平、APACHEⅡ积分及并发症发生率与死亡率。结果治疗后对照组IL-6、PCT及CRP水平、死亡率、并发症发生率、APACHEⅡ积分均高于观察组,临床疗效差于观察组,差异有统计学意义(P<0.05)。结论给予SAP患者CVVH治疗效果显著,可明显降低IL-6、PCT及CRP水平,改善预后。

Objective To discuss the influence of peripheral blood IL-6, PCT and CRP of the patients with severe acute pancreatitis（SAP） by given the continuous venovenous hemofiltration（CVVH）. Methods 60 cases of patients with SAP in our hospital were selected, to randomly divided into two groups, 30 cases in each group. The control group was implemented the routine treatment, the treatment group was implemented the CVVH for treatment, to compared the IL-6, PCT and CRP level, APACHE Ⅱscore and death rate of them. Results After treatment, the IL-6, PCT and CRP level, death rate and APACHE Ⅱ score of the control group was significantly greater than the treatment group, there was statistical significance（P〈0.05）. Conclusion That significant effect of patients with SAP treated by CVVH, that able to significantly reduce the IL-6, PCT and CRP level, and to improve the prognosis.