红花注射液治疗脑梗死患者的临床效果评析

Evaluation on Clinical Effect of Safflower Injection on Patients With Cerebral Infarction

目的对确诊为脑梗死的患者进行红花注射液治疗,观察其治疗效果。方法对2014年2月~2016年2月50例在本医院进行治疗及康复的脑梗死患者采用红花注射液治疗,观察治疗前后梗死体积大小变化、治疗前后血液流变学指标以及神经功能改变情况,同时记录患者服药期间不良反应,对其用药安全性进行评价。结果 50例患者治疗后梗死体积由（14.23±2.14）cm2降为（7.23±1.34）cm2,神经功能缺损评分由（29.23±4.23）降低至（9.65±1.05）,同时纤维蛋白原、全血粘度的低切值、高切值、红细胞压积等血液流变学指标均较治疗前改善,差异有统计学意义（P〈0.05）。经过跟踪随访,共出现3例不良反应,属于正常范围。结论对确诊为脑梗死的患者进行红花注射液治疗能够改变其血液流变学指标、减小梗死体积,使脑梗死患者各项生体机能有效恢复。

Objective To investigate the effect of safflower injection on patients with cerebral infarction. Methods 50 patients with cerebral infarction were treated with safflower injection in our hospital from February 2014 to February 2016. Before and after treatment, the changes of infarct size, the changes of hemorheology and neurological function before and after treatment were observed. At the same time, the adverse reactions of patients were recorded, and the drug safety was evaluated. Results The infarct volume decreased from（14.23±2.14） cm2 to（7.23±1.34） cm2 after treatment of 50 cases, and the scores of neurological deficit decreased from（29.23±4.23） to（9.65±1.05）, while the levels of fibrinogen High shear, hematocrit and other hemorrheological indicators were significantly improved compared with before treatment, the difference was statistically significant（P 〈 0.05）. After follow-up, there were a total of 3 cases of adverse reactions which were within the normal range. Conclusion Safflower injection can improve hemorrheological indexes of cerebral infarction patients, reduce infarct volume, and effectively restore the function of cerebral infarction patients.