TGF-β--Smad信号通路和上皮细胞-间充质转化在支架后血管狭窄中的研究进展

Progresses of TGF-β—Smad signaling pathways and epithelial-mesenchymal transition in stented blood vessel stenosis

血管支架术后存在着较高的支架处再狭窄风险,其中转化生长因子-β(TGF-β)—Smad信号通路、上皮细胞-间充质转化(EMT)等发挥了重要的作用。本文对TGF-β—Smad信号通路、EMT在血管支架术后再狭窄过程中的作用及相关机制进行综述。

There is a high risk of re-stenosis after implanting blood vessels stent, the processes involves the transforming growth factor-β （TGF-β）-Smad signaling pathways, epithelial-mesenchymal transition （EMT） and so on. The function of TGF-β-Smad signal pathways and EMT in vascular stent re-stenosis and the relevant mechanism were reviewed in this paper.