慢萎颗粒对高原地区萎缩性胃炎异型增生及肠化生患者氨基己糖、表皮生长因子的作用

Effect of Manwei granule on HS and EGF in patients with DYS and IM of chronic atrophic gastritis at high altitude area

目的:探讨慢萎颗粒对高原地区慢性萎缩性胃炎(CAG)患者氨基己糖(HS)、表皮生长因子(EGF)水平的影响。方法:选择符合CAG伴异型增生(Dys)和(或)肠化生(IM),中医辨证属气虚血瘀的患者共80例,随机分为治疗组40例,对照组40例。治疗组采用慢萎颗粒口服,对照组采用摩罗丹口服,用药6周。观察两组治疗前后临床症状、胃黏膜病理的变化,检测两组治疗前后胃液HS及EGF水平变化。结果:慢萎颗粒在缓解萎缩性胃炎患者临床症状方面较摩罗丹组明显为好;在改善胃镜下异型增生及肠化方面明显优于摩罗丹组;能明显降低萎缩性胃炎黏膜EGF水平;能明显提高萎缩性胃炎黏膜HS水平。结论:慢萎颗粒能较好的缓解萎缩性胃炎患者的临床症状,改善胃镜下胃黏膜病理组织异性增生及肠化生,能提高萎缩性胃炎黏膜HS水平,降低萎缩性胃炎黏膜EGF水平。

Objective： To explore the effect of Manwei granule on hexosamin（HS） and Epidermal Growth Factor（EGF） in patients with DYS and IM of chronic atrophic gastritis at high altitude area. Melhods： The clinic research selects 80 patients,which comply with DYS and （or）IM of CAG,and qi-defieiency-blood-stasis syndrome based on the TCM,they were randomly divided into the treatment group （40 cases） and the contrast group （40 eases）. The treatment group was raked by ManWei granule and the contrast group was taked by Moluodan,time is 6 weeks. To observe symptom, pathological change of gastric mueosa, testing HS and EGF level changes before and after treatment, and compared with clinical effect. Results： ManWei granule has a better clinical effect than Moluodan group, the index showed notable change（ P 〈 0.05orP 〈0.01 ）. It has a signifieandy improvement in DYS and （or）IM of CAG than Moluodan group（P 〈0.05）. The EGF level was declined sig- nificantly as compared with pretreation and treatment group （ P 〈 0.05 ）. The HS level was significantly higher than those in pretreation and treatment group （ P 〈 0.05 ）. Conclusion： ManWei granule can better cure symptom and improve DYS and （or） IM of CAG, meanwhile, it can increase the HS level and decline the EGF level.