银杏内酯注射液辅助治疗高血压脑出血疗效及对神经功能恢复的影响

The effect of Ginkgolides Injections on hypertensive cerebral hemorrhage and hearological function

目的:观察银杏内酯注射液辅助治疗高血压脑出血疗效及对神经功能恢复的影响。方法:纳入2014年1月至2015年4月科室收诊疗的高血压脑出血患者62例,按随机数字表法分为治疗组及对照组各31例,所有患者均行微创血肿清除术,对照组患者术后给予止血、营养等对症治疗,治疗组患者在对照组常规基础上加用银杏内酯注射液辅助治疗。分析治疗后不同方案的治疗效果,对治疗前和治疗后两组患者血清白蛋白(Albumin,ALB)、血浆神经元特异性烯醇化酶(Neuron-specific enolase,NSE)、白介素-6(Interleukin-6,IL-6)、肿瘤坏死因子-ɑ(Tumor necrosis factor-ɑ,TNF-ɑ)、超敏C-反应蛋白(Hypersensitive C-reactive protein,hsCRP)、运动功能评分Fugl-Meyer、格拉斯哥昏迷评分(Glasgow Coma Scale,GCS)、美国国立卫生院神经功能缺损评分(National Institute of Health stroke scale,NIHSS)进行分析。结果:治疗组治疗后总有效率为67.74%,显著高于对照组38.71%;治疗后治疗组ALB、NSE水平分别为(36.73±1.34g/L、12.46±1.75ug/L),均明显优于对照组(33.85±1.00g/L、16.27±2.39ug/L);3治疗组治疗后IL-6、TNF-ɑ水平分别为(13.55±2.90、2.08±0.32)ug/L,均明显优于对照组(22.64±3.17、3.16±0.49)ug/L;4治疗后治疗组患者hs-CRP水平和Fugl-Meye得分分别为(16.82±2.73mg/L、75.58±9.11分),均明显优于对照组(25.67±3.24mg/L、60.44±7.12分)。5治疗组治疗后GCS评分和NIHSS评分分别为(10.55±1.10、13.64±1.74)分,均明显优于对照组(8.82±1.07、17.08±2.42)分。结论:银杏内酯注射液对高血压脑出血具有良好的辅助作用,可调节患者体内炎症因子,改善患者的生存质量,促进患者神经功能恢复的恢复。

Objective： To research the effect of Ginkgolides Injection on hypertensive cerebral hemorrhage and neurologica function. Methods： 62 patients from January 2014 to April 2015 ,were randomly divided into treatment group and control group, 31 cases respectively. All patients encountered minimally invasive hematoma, the control group patients reeejved symptomatic treatments, such as bleeding, giving nutrition except symptomatic treatment, patients in the treatment group were given Ginkgolides Injection stopping. We recorded and analyzed the data of serum albumin （albumin,ALB） , serum neuron-specific enolase （NSE） , interleukin -6 （IL-6） , tumor necrosis factor -α （TNF-α） , hyper- sensitivity reactions C- protein （ hs-CRP）, motor function score Fugl-Meyer, Glasgow coma score （ GCS）, the US National Institutes of Health neurological deficits （NIHSS） of two groups patients before and after treatment. Results： The total effective rate of the treatment group was 67.74% significantly higher than 38.71% of the control group （ P 〈 0.05 ）. After treatment, compared with the control group the ALB, NSE levels of the treatment group （ 36.73 ± 1.34g/L, 12.46 ± 1.75 ug/L） were obviously improved （ 33.85 ± 1.00g/L, 16.27 ± 2. 39ug/L） （P 〈0.05 ） ; ③The IL-6, TNF-α levels of the treatment group （13.55 ± 2.90,2.08 ± 0.32 ）ug/L were obviously higher than the control group （22.64 ± 3.17,3.16 ± 0.49 ug/L） （ P 〈 0.05 ） ; ④The hs-CRP levels and Fugl-Meye score of the treatment group were （ 16. 82±2.73mg/L,75.58 ±9.11mg/L, respectively after treatment） , were improved, compared to the control group （25.67 ±3.24mg/L, 60. 44 ± 7.12 min） , and the differences were statistically significant （P 〈0.05 ）. ⑤The GCS score and NIHSS scores of the treatment group （ 10.55 ± 1.10,13.64 ± 1.74 ） were improved than that of the control group （ 8.82 ± 1.07,17.08 ± 2.42）. Conclusion： Ginkgolides Injection hypertensive intracerebral hemorrhage, can regulate inflammatory factors in patients, improve the quality of life of patients, promote the recovery of neurological function recovery.