红花注射液联合辛伐他汀治疗高脂血症的临床观察

Clinical efficacy of Safflower Injection combined with simvastatin in the treatment of hyperlipidemia

目的:观察红花注射液联合辛伐他汀治疗高脂血症的临床疗效。方法:纳入2014年3月至2015年6月我院收治的高脂血症患者103例,按随机数字表法分为观察组(n=51例)和对照组(n=52例)。治疗方案为对照组给予辛伐他汀治疗,观察组给予红花注射液联合辛伐他汀治疗。记录并分析两组患者治疗前和治疗后总胆固醇(Total cholesterol,TC)、甘油三酯(Triglyceride,TG)、高密度脂蛋白胆固醇(High-density lipoprotein-C,HDL-C)和低密度脂蛋白胆固醇(Low-density lipoprotein-C,LDL-C)、血清载脂蛋白A1(Apoli popro tein A1,Apo A1)水平和载脂蛋白B(Apoli popro tein B,Apo B)水平的变化、临床疗效以及不良反应。结果:治疗后两组TC和TG水平均下降,但观察组TC和TG水平为(5.11±0.25、1.83±0.10)mmol/L均显著低于对照组(6.10±0.36、2.11±0.15)mmol/L。治疗后两组患者的HDL-C水平均上升,LDL-C水平均下降,但观察组HDL-C和LDL-C水平为(1.29±0.16、2.86±0.27)mmol/L,均优于对照组(1.10±0.15、3.65±0.34)mmol/L。3治疗后两组患者血清载脂蛋白A1(Apo A1)水平和治疗前无统计学差异,且组间相比也无统计学差异,治疗后两组载脂蛋白B(Apo B)水平均下降,且观察组患者Apo B水平为(0.91±0.11)mmol/L,显著低于对照组(1.22±0.16)mmol/L。4观察组治疗后总有效率为92.16%,显著高于对照组73.08%。5观察组治疗过程中不良反应率为9.80%,和对照组相5.77%相比,差异不具有显著性。结论:红花注射液联合辛伐他汀可有效调节患者体内总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇水平,且不良反应较低,是一种安全有效的治疗方案。

Objective： To study the clinical efficacy of Safflower Injection combined with simvastatin in the treatment of hyperlipidemia. Methods： 103 patients with hyperlipidemia , from March 2014 to June 2015 , were randomly divided into simvastatin group （n = 52） and safflower in- jection combined with simvastatin group （n = 51 ）. Total cholesterol （TC）, triglycefide （TG）, high density lipoprotein cholesterol （HDL-C） ,low density lipoprotein cholesterol （LDL-C） ,Apoli popro tein A1 （ApoA1） and Apoli popro tein B（ApoB） levels, clinical efficacy and adverse reactions of two groups of patients were recorded and analyzed before and after treatment. Results： ①After treatment, TC and TG levels in two groups decreased, and TC and TG levels of the combination drug group （5.11 ±0.25,1.83 ± 0.10mmol/L）, was significantly lower than them of simvastatin the group （6.10 ± 0.36,2.11 ± 0. 15mmol/L） （ P 〈 0.05）. ②After treatment, HDL-C level of two groups of patients increased, LDL-C level decreased, and the differences of HDL-C and LDL-C levels of the combination drug group were （ 1.29 ± 0. 16,2.86 ±0.27mmol/L）, obvious than simvastatin group （ 1.10 ±0.15,3.65 ±0.34retool/L） （P 〈0.05）. ③After treatment, ApoA1 level of two groups of patients had no obvious changes（P 〉0.05）. ApoB level reduced,but ApoB levels of combination drug group（0.91 ±0. 11 mmol/L） ,were lower than simvastatin group （ 1.22 ± 0.16mmol/L） （ P 〈 0.05 ） . ④After treatment, the total effective rate of group was 92.16%, significantly higher than 73.08% of simvastatin（ P 〈 0.05）. ⑤ Combination drug in combination drug adverse reactions group was 9.80%, and 5.77% in the simvastatin group, the difference was not significant （ P 〉 0.05）. Conclusion： Safflower Injection can effective- ly improve total cholesterol, triglycefides, high density lipoprotein cholesterol and low density lipoprotein cholesterol, and it has few side effects.