肿瘤乏氧检测研究新进展

Recent advances in hypoxic tumor detection

在肿瘤内部存在乏氧区域,肿瘤的乏氧与肿瘤的抗化疗、放疗及恶性程度等密切相关.对肿瘤内部的乏氧区域进行成像可能有助于研发新的癌症诊断与治疗的方法,此领域越来越受到广泛的关注.本文主要针对近年来对肿瘤乏氧成像中乏氧探针的设计、合成及应用研究的最新进展进行综述,主要包括对肿瘤乏氧还原环境响应探针及氧气淬灭乏氧探针的介绍等.

Hypoxia is an important characteristic of malignant solid tumors and is considered as a possible causative factor for the resistance to chemo- and radiotherapy.The exploration of novel fluorescent probes capable of detecting hypoxia in solid tumors has attracted increasing attention.This review highlights some recent progress in the design,synthesis and application of fluorescent probes for hypoxia.