大肠癌患者抑郁症状与CD4^+CD25^+调节性T细胞不相关

Non-correlation study of depressive symptomps and CD4^+CD25^+ regulatory T cells in colorectal cancer patients

目的分析大肠癌患者抑郁、焦虑等症状与调节性T细胞(Regulatory T cell,Treg)的相关性,探索抑郁、焦虑症状影响大肠癌发生、发展的可能机制。方法通过横断面调查法选取大肠癌病例组72人及正常对照组44人,评估焦虑、抑郁状态,人格特征等;采用流式细胞术检测调节性T细胞所占比例。结果大肠癌组抑郁及艾森克人格量表(EPQ)的神经质维度(EPQ-N)评分高于对照组(P<0.05)。大肠癌组抑郁不同程度的发生率高于对照组(P<0.05)。大肠癌组CD4^+CD25^+Treg(%)和CD4^+CD25^+FOXP3^+Treg(%)高于正常对照组(P<0.05)。大肠癌组焦虑评分与对照组无差异(P>0.05),大肠癌组和正常对照组的CD4^+(%)和CD4^+/CD8^+无差异(P>0.05),大肠癌患者的调节性T细胞与汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)总分无相关性(P>0.05)。结论术前大肠癌组患者抑郁症状和神经质人格的发生比率高于一般人群。大肠癌患者术前调节性T细胞升高,存在免疫抑制,但其调节性T细胞与抑郁症状可能无关。

Objective To analyze the correlation between depression and anxiety, and other regulatory T cells in patients with colorectal cancer, and to explore the possible mechanism of depression and anxiety on the occurrence and development of colorectal cancer. Methods 72 cases of colorectal cancer and 44 cases of normal control group were selected by cross-sectional survey to evaluate the anxiety, depression and personality characteristics. The proportion of regulatory T cells was detected by flow cytometry. Results The total score of depression and EPQ-N in colorectal cancer group was significantly higher than that in normal control group （P〈0.05）. There was significant difference for the incidence of different severity of depressive symptoms between colorectal cancer group and control group（P〈0.05）. CD4＋ CD25＋ Treg （%） and CD4＋ CD25＋ FOXP3Treg （%） in eolorectal cancer group were significantly higher than those in normal control group（P〈0.05）. There was no significant difference between the colorectal cancer group and the control group in the total scores of anxiety（P〉0.05）. There was no significant difference in the incidence of anxiety symptoms between colorectal cancer group and normal control group（P〉0.05）. The difference for CD4＋ （CD4＋ / CD8＋） and CD4＋ / CD8＋ between eolorectal cancer group and normal control group was not statistically significant（P〉0.05）. There was no significant correlation between regulatory T cells and total HAMD score in patients with coloreetal cancer. Conclusion The depressive symptoms and the incidence of neurotic personality are higher in preoperative colorectal cancer patients than in population, but not related to pegulatory T cells.