PI3K/Akt和AMPK信号通路在运动诱导的啮齿动物骨骼肌内GLUT4转位和表达中的作用

PI3K/Akt and AMPK Signaling Pathway and Effect of Exercise on Rodent Skeletal Muscle GLUT4 Translocation and Expression

骨骼肌在葡萄糖稳态中扮演重要作用,葡萄糖转运体4(glucose transporter4,GLUT4)作为骨骼肌内最主要的葡萄糖转运蛋白,其转位和表达的变化与胰岛素抵抗的发生密切相关。本文综述了近年来关于啮齿动物骨骼肌内GLUT4转位和表达的运动激活以及磷脂酰肌醇-3-激酶(phosphatidylinositol 3-kinases,PI3K)/蛋白激酶B(protein kinase B,Akt)和腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)信号通路介导运动改善骨骼肌葡萄糖摄取的研究进展,旨在为全面了解和明确运动影响啮齿动物骨骼肌内GLUT4转位和表达的机制。

Skeletal muscles play an important role in glucose homeostasis. The translocation and expression changes of glucose transporter 4 （GLUT4） as one of the most important glucose transporter proteins in skeletal muscle are closely associated with insulin resistance. This paper reviewed the recent research progress on the exercise-induced translocation and expression of GLUT4 as well as the improvement of exercise-induced glucose uptake by phosphatidylinositol 3-kinases （PI3K） / protein kinase B （Akt） and AMP-activated protein kinase （AMPK） signaling pathways in rodent skeletal muscle. The purpose of this paper is to clearly understand the mechanism underlying GLUT4 translocation and expression in rodent skeletal muscles.