基于倾向性评分法分析参附注射液对肾功能的影响

The effect of Shenfu injection on renal function based on propensity score method

目的研究参附注射液对患者肾功能的影响。方法基于全国18家三甲医院的医院信息系统(HIS)数据库进行研究,数据由使用参附注射液患者25 704例和未用参附注射液患者51 898例信息构成。从2组人群中分别提取具有血尿素氮(BUN)和血肌酐(SCr)指标,年龄在18~80岁之间的患者作为研究对象。采用倾向评分法去除混杂因素,分析临床使用参附注射液对肾功能是否产生影响。结果使用Logistic分析参附注射液对BUN、SCr的影响,P均<0.05;使用加权后的Logistic分析参附注射液对BUN、SCr的影响,P均<0.05,而带协变量的倾向评分加权后BUN P>0.05,而SCr P<0.05。结论我们认为使用参附注射液对BUN异常变化的影响不显著,对SCr异常变化的影响显著。

Objective To study the effect of Shenfu injection on renal function.Methods Based on hospital information system（HIS）,25 704 patients who were given Shenfu injection and 51 888 patients who hadn＇t given Shenfu injection were involved in this study.Among the patients,blood urea nitrogen（BUN） and serum creatinine（SCr） of patients,and the patients aged 18~80 were recruited in this study.Propensity score method was used to wipe off the effect of Shenfu injection on renal function.Results Logistic analysis was used to analyze the effect of Shenfu injection on BUN and SCr（P〈0.05）,After weighing,Logistic analysis showed the effect of Shenfu injection on BUN and SCr were significant（P〈0.05）.But after propensity score weighted with a covariate,P value of BUN was lager than 0.05,while the P value of SCr was smaller than 0.05.Conclusion Shenfu injection has no obvious influence on BUN,and great influence on SCr.