复方甘草酸苷与卡泊三醇软膏治疗寻常型银屑病的效果及对辅助性 T 细胞17的影响

Gfficacy of compound glycyrrhizin combined with calcipotriol ointment on psoriasis vulgaris and T helper cell 17

目的：探讨复方甘草酸苷与卡泊三醇软膏治疗寻常型银屑病疗效及对辅助性 T 细胞17（Th17）的影响。方法选取2014年12月至2015年12月寻常型银屑病患者104例，随机分为两组，每组52例。单一组采用卡泊三醇软膏治疗，联合组采用卡泊三醇软膏及复方甘草酸苷联合治疗。比较两组治疗效果及治疗前后观察指标水平变化。结果联合组总有效率为90.38%（47/52），单一组为69.23%（36/52），两组比较差异有统计学意义（P 〈0.05）。治疗后，联合组观察指标水平均优于单一组，差异有统计学意义（P 〈0.05）。结论联合采用复方甘草酸苷及卡泊三醇软膏治疗寻常型银屑病患者效果显著，可有效改善 Th17及其他相关细胞因子表达水平，提高治疗效果。

Objective To investigate the effect of compound glycyrrhizin combined with calcipo-triol ointment on psoriasis vulgaris and T helper cell 17. Methods A total of 104 patients with psoriasis vulgaris from December 2014 to December 2015 were selected,and were randomly divided into the two groups,with 52 cases in each group. The single group was given calcipotriol ointment and the combina-tion group was treated with calcipotriol ointment and compound glycyrrhizin. The effects and index level changes before and after treatment of the two groups were compared. Results The total effective rate of the combination group was 90. 38%（47 / 52）,and that of the single group was 69. 23%（36 / 52）,the difference was significant between the two groups（P 〈 0. 05）. After treatment,the indexes of the com-bined group were better than that of the single group,and the differences were significant（P 〈 0. 05）. Conclusions The effect of compound glycyrrhizin and calcipotriol ointment on psoriasis vulgaris is sig-nificant,which can effectively improve the expression of Th17 and other related cytokines,and can im-prove the therapeutic effect.