摘要
目的:探讨不同炮制方法对补骨脂中抗骨质疏松有效成分含量的影响。方法:采用HPLC法测定补骨脂生品及不同炮制品中香豆素类、黄酮类、单萜酚类抗骨质疏松效应成分的含量,对炮制前后三类成分的含量进行统计分析。结果:补骨脂经不同方法炮制后三类成分含量与生品相比均有极显著变化。结论 :药典收载的炮制法可同时提高三类化合物的含量,可能增强其治疗骨质疏松的作用,与中医认为"盐炙能增强温补脾肾的作用"的传统观念相吻合。
This study aimed at evaluating the effect of different processing methods on the contents of antiosteoporotic compositions in P. corylifolia. HPLC method adopted to analyze the contents of antiosteoporotic compositions, including coumarin（psoralen and isopsoralen）, flavonoids（neobavaisoflavone, corylifolin, corylifolinin and corylifol A） and meroterpenes（bakuchiol） in P. corylifolia. The contents were analyzed before and after the processing methods. Results： The results showed that the content of coumarin, flavonoids and meroterpenes obviously changed in different processed P. Corylifolia in comparison with the crude drugs. In conclusion, it was demonstrated that the therapeutic efficacy of osteoporosis was enhanced by CP method which increased all of the three compositions. The testimony tallied with the Chinese medical theory： stir-frying with salt-water could enhance the effect of the tonification of spleen and kidney.
出处
《世界科学技术-中医药现代化》
CSCD
2017年第1期127-132,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委青年科学基金项目(81202911):补骨脂炮制前后骨质疏松药效的变化及相关炮制机理研究
负责人:颜冬梅
关键词
补骨脂
炮制
抗骨质疏松效应成分
影响
Psoralea corylifolia L.
processing method
antiosteoporotic composition
effect
