脓毒症的前世今生

Sepsis in the Past and Now

自1991年脓毒症首次被提出以来,脓毒症的定义和诊断标准不断更新和完善,今年已经是"第三版"(Sepsis 3.0),每次更新都融入许多新的理论或观点,但同时也充满了争议,在这种争议和讨论中脓毒症的定义和诊断标准趋于更加完善。它代表了我们对感染引起的患者全身炎症反应以及后续器官功能障碍等病理生理机制或状态认识水平的不断提高,是与当前医疗现状密不可分的。本文就脓毒症的整个发展历程和相关争论进行详述,期望大家从理论上更好地理解脓毒症的内涵。

The definition and diagnosis criteria of Sepsis constantly updated and improved since 1991 when it was proposed in the first time,and now is ＂the third edition＂（Sepsis 3.0）.Many new theories or opinions had been proposed,but also full of controversy.Through those dispute and discuss,the definition and diagnosis of sepsis is improving.It represents our enhanced level of the understanding to the pathophysiological mechanisms of systemic inflammatory response syndrome and subsequent organ dysfunction in patients with infection,and is matched correspondingly with the current medical conditions.I narrate the all development and debate of sepsis for detail in the paper,and expect the connotation of sepsis will be understood deeply.