埃索美拉唑与奥美拉唑治疗胃溃疡的疗效比较

Efficacy of Esomeprazole Versus Omeprazole in the Treatment of Gastric Ulcer

目的观察埃索美拉唑三联法与奥美拉唑三联法治疗胃溃疡的临床疗效。方法良性胃溃疡患者180例均伴有幽门螺杆菌,随机均为对照组90例,观察组90例。对照组给予奥美拉唑为主的三联法治疗;观察组给予埃索美拉唑为组的三联法治疗,两组疗程均为8周。治疗后观察两组患者的溃疡愈合率,临床症状缓解情况,Hp的根除率及不良反应。结果观察组治疗后治愈22例、显效42例,总有效率为93.3%,对照组治疗后治愈18例、显效30例,总有效率为78.9%,两组比较有统计学意义(P<0.05)。Hp根除情况:对照组79例根除,根除率为87.8%,观察组82例根除,根除率为91.1%,两组Hp根除率比较,差异无显著性意义(P>0.05)。结论应用埃索美拉唑三联法治疗伴有幽门螺杆菌(Hp)的胃溃疡能够有效的促进溃疡愈合,不良反应少治疗效果明显优于奥美拉唑,值得临床推广。

Objective To observe the clinical efficacy of gastriculcers with esomeprazole and omeprazole triple law Therapy. Methods 180 patients with benign gastric ulcer are associated with Helicobacter pylori（Hp）.The control group 90 cases received omeprazole-based triple therapy method; observation group 90 cases received esomeprazole treatment group for the triple law, for 8 weeks. Observed clinical remission, Hp eradication rate and adverse reactions in both groups of patients. Results After treatment, the observation group were cured 22 cases, 42 cases show, the total effective rate was 93.3% in the control group 18 cases were cured, 30 cases of apparent effect, the total effective rate was 78.9%, the two groups was statistically significant （P〈0.05）. The control group 79 cases of Hp eradication, eradication rate was 87.8%; the observation group 82 cases eradicate, eradication rate was 91.1%, the difference was not significant （P〉0.05）. Conclusion Esomeprazole three treatment with Hp in gastric ulcer can effectively promote ulcer healing, fewer adverse reactions treatment is better than omeprazole.