度洛西汀治疗功能性消化不良伴焦虑抑郁的应用研究

Application of duloxetine in patients with functional dyspepsia complicated with anxiety and depression

目的研究度洛西汀在治疗功能性消化不良伴焦虑抑郁中的应用研究。方法 96例功能性消化不良伴焦虑抑郁患者根据是否服用度洛西汀治疗,按随机数字表法平均分为对照组和治疗组,对照组进行常规治疗,治疗组在此基础上加服度洛西汀,均治疗8周。比较2组治疗前、治疗后2、4、8周功能性消化不良、抑郁、焦虑和生活质量改善情况以及不良反应。结果治疗后2、4、8周,2组消化不良症状积分呈显著降低趋势,治疗后2组差异具有统计学意义(P<0.05);治疗组治疗后2、4、8周消化不良改善总有效率分别为81%、89%、94%;对照组为60%、67%、73%,2组差异具有统计学意义(P<0.05);2组治疗后汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)和临床疗效总评分量表(CGI-S1)评分随治疗时间呈显著降低趋势,且治疗组治疗后4、8周下降幅度显著高于对照组,差异具有统计学意义(P<0.05);治疗后8周,2组生活质量评分显著提高(P<0.05),且治疗组提升幅度显著高于对照组,差异具有统计学意义(P<0.05);治疗组总不良反应率21%,对照组19%,2组差异无统计学意义(P>0.05)。结论度洛西汀治疗功能性消化不良伴焦虑抑郁疗效显著,可显著提升患者生活质量,安全有效,值得临床推荐。

Objective To study the application of duloxetine in patients with functional dyspepsia （FD） complicated with anxiety and depression. Methods Ninety-six patients with FD complicated with anxiety and depression were equally divided into the control group and the treatment group according to the use of duloxetine. Patients in the control group were given routine treatment. On that basis, patients in the treatment group were treated with duloxetine and both groups were treated for 8 weeks. Relief of FD, depression, anxiety, improvement of quality of life and adverse reactions were compared between the two groups before treatment, at 2, 4 and 8 weeks after the treatment. Results Two, 4 and 8 weeks after treatment, the scores of adverse reactions in both groups decreased significantly, and there was significant difference between the two groups （ P 〈0.05） ; 2, 4 and 8 weeks after treatment, the total effective rates of relieving FD in the treatment group （81%, 88%, 94%） were significantly higher than those in the control group （60%, 67%, 73%） （P 〈 0. 05）; After treatment, the HAMD, HAMA and CGI-S1 scores of two groups were significantly decreased over time, and the decreasing ranges in treatment group were significantly higher than those in control group at 4 week and 8 weeks after treatment （ P d0.05） ; 8 weeks after treatment, the quality of life scores of the two groups increased significantly （ P 〈0.05 ）, and quality of life score in treatment group was significantly higher than that in control group （ P 〈0. 05） ; The total incidence of adverse reactions in the treatment group was 21% while it was 19% in the control group （P〈0.05）. Conclusion Duloxetine is effective for treating FD with anxiety and depression. It can improve the quality of life of patients. And it is safe and effective, and worthy of clinical promotion.