良性前列腺增生患者下尿路症状与前列腺组织学炎症的相关性分析

The correlation analysis of LUTS and histological inflammation in patients with benign prostatic hyperplasia

目的：探讨良性前列腺增生（BPH）患者下尿路症状（LUTS）与前列腺组织学炎症程度、类型的相关性。方法2013年10月至2016年6月收治的 BPH 患者150例，年龄62～82岁。择期行经尿道前列腺电切术（TURP），术后前列腺组织送病理检查。根据国际前列腺炎组织学分类标准，将患者分为 A 组（无炎症）18例、B 组（腺周炎症）45例、C 组（腺体炎症）33例，D 组（混合型）54例，四组患者年龄、病程、尿潴留次数、前列腺体积之间的差异无统计学意义（均 P ＞0．05）。观察四组患者术前、术后2个月 IPSS 评分及其与组织学炎症程度、类型的相关性。结果A 组术前及术后2月 IPSS 评分分别为（17．20±11．14）分、（8．45±5.14）分，与 C 组的（18．05±13．11）分、（9．85±5．25）分差异无统计学意义（t ＝0．485、1．294，均 P ＞0．05）；B组[（22．55±11．85）分、（13．24±6．46）分]与 D 组[（21．45±10．35）分、（12．36±6．04）分]差异无统计学意义（t ＝0．824、1．436，均 P ＞0.05）。B 组与 A、C 组差异有统计学意义（t ＝2．689、5．016、3．642、4．382，均 P ＜0.05）；D 组与 A、C 组差异有统计学意义（t ＝2．786、4．672、6．415、5．106，均 P ＜0．05）。B、D 组术前及术后2个月 IPSS 评分与炎症程度呈正相关（B 组：r ＝0．698、0．795，D 组：r ＝0．546、0．485，均 P ＜0．05），C 组与炎症程度无相关性（r ＝0．182、0．170，均 P ＞0．05）。结论BPH 患者的 LUTS 症状与前列腺组织中腺周炎症关系密切，且随腺周炎症的增加而加重，与腺体炎症无关。

Objective To investigate the relationship between LUTS and degree,type of prostate histological inflammation in patients with benign prostatic hyperplasia （BPH）.Methods From October 2013 to June 2016, 150 patients with BPH（62 -82 years old）were treated with selective TURP.After operation,the pathology examina-tion was practised.According to the international prostatitis histological classification standard,the patients were divid-ed into group A（without inflammation,18 cases）,group B（inflammation around gland,45 cases）,group C（gland inflammation,33 cases）and group D（mixed inflammation group,54 cases）.There were no statistically significant differences among the 4 groups in age,course of disease,number of urinary retention and prostate volume（all P 〉0.05）.The IPSS score before and 2 months after operation and the correlation between the IPSS and degree,type of histological inflammation were observed.Results In group A and C,the preoperative IPSS score and IPSS score at 2 months after surgery were （17.20 ±11.14）points,（8.45 ±5.14）points and （18.05 ±13.11）points,（9.85 ± 5.25）points respectively,there were no statistically significant differences between the two groups（t =0.485,1.294, all P 〉0.05）.There were no statistically significant differences between group B[（22.55 ±11.85）points,（13.24 ± 6.46）points]and group D[（21.45 ±10.35）points,（12.36 ±6.04）points]（t =0.824,1.436,all P 〉0.05）.The group B had statistically significant differences compared with group A and group C （t =2.689,5.016,3.642,4.382, all P 〈0.05）.The group D also had statistically significant differences compared with group A and group C （t =2.786,4.672,6.415,5.106,all P 〈0.05 ）.There was positive correlation between the IPSS score before and 2 months after operation and the degree of inflammation in group B,D（B：r =0.698,0.795,D：r =0.546,0.485,all P 〈0.05）,but there was no correlation in group C between them（r =0.182,0.170,all P 〉0.05 ）.Conclusion There is a close correlation between LUTS and inflammation around gland in patients with BPH,and the LUTS can＆nbsp;aggravate with the increased inflammation around gland and do not relate with the gland inflammation.