人高危型乳头瘤病毒检测联合液基薄层细胞学在宫颈癌和癌前病变筛查中的应用价值

The application value of HR -HPV detection combined with TCT in the screening of cervical cancer and pre-cancerous lesions

目的：探讨通过筛查人高危型乳头瘤病毒（HR-HPV）结合液基薄层细胞学（TCT）检查在诊断宫颈癌及癌前病变中的价值。方法选取经病理学检查的1198例宫颈标本进行研究，对患者的 HR-HPV 检测结果、TCT 检测结果进行分析，以病理学结果为金标准，探讨 HR-HPV、TCT 检测单独应用及两者联合应用在诊断宫颈癌、癌前病变中的价值。结果随着病理学检查分级的升高，TCT 检查阳性率逐渐增高，两者有相关性（r ＝0．629，P ＜0．05）；随着病理学检查分级的升高，HR-HPV 检查阳性率逐渐增高，两者有相关性（r ＝0.684，P ＜0．05）。HR-HPV 结合 TCT 鉴别诊断宫颈癌、癌前病变的灵敏度100．00％、特异度79．64％、漏诊率0．00％、误诊率20．36％。结论HR-HPV 结合 TCT 检查在诊断宫颈癌及癌前病变中具有较高的临床实用价值。

Objective To explore the diagnostic value of HR -HPV combined with TCT in the diagnosis of cervical cancer and precancerous lesion.Methods 1 198 cervical specimens were selected for the study.The results of HR -HPV detection and TCT detection were analyzed,with the pathological results as the gold standard,the diag-nostic value of HR -HPV and TCT in the diagnosis of cervical cancer and precancerous lesion were discussed. Results With increasing pathological grade,TCT positive rate increased gradually,there was a correlation between them（r =0.629,P 〈0.05）.With increasing pathological grade,HR -HPV positive rate increased gradually,there was a correlation between them（r =0.684,P 〈0.05）.The sensitivity of HR -HPV combined with TCT in the differ-ential diagnosis of cervical cancer,precancerous lesions was 100.00%,specificity was 79.64%,missed diagnosis rate was 0.00%,the misdiagnosis rate was 20.36%.Conclusion HR -HPV combined with TCT examination has high clinical value in the diagnosis of cervical cancer and precancerous lesions.