LncRNA与结直肠癌诊断治疗的研究进展

Progress on Long Non-coding RNA in Diagnosis and Treatment of Colorectal Cancer

结直肠癌(CRC)是常见的恶性肿瘤之一,严重威胁着人类的健康。目前大量的研究表明异常表达的长链非编码RNA(lnc RNA)通过影响肿瘤细胞的增殖、凋亡、迁移及侵袭等生物学行为参与了CRC的发生发展,并且发现lnc RNA的单核苷酸多态性(SNPs)与CRC的易感性密切相关。因此,针对lnc RNA的深入研究有望为CRC的诊断和治疗提供新的手段。

Colorectal cancer（CRC） is one of the most common malignant diseases. At present,studies have indicated that dysregulated long non-coding RNA（lnc RNA） are involved in the tumorigenesis and progression of CRC by affecting on various biological behavior,including the proliferation,apoptosis,migration and invasion of tumor cells. Moreover,emerging evidence has revealed that single nucleotide polymorphisms（SNPs） of lnc RNA are closely related to the susceptibility of CRC. Further study on lnc RNA may provide a new approach for diagnosis and treatment of CRC.