尤瑞克林联合高压氧对急性脑梗死治疗的临床疗效评价

Clinical curative effect evaluation of urinary kallidinogenase combined with hyperbaric oxygen on acute cerebral infarction

目的探讨急性脑梗死采用尤瑞克林与高压氧联合治疗的临床效果。方法选取2014年2月至2016年2月的急性脑梗死患者100例,随机分为两组,对照组50例采取常规治疗如抗血小板聚集等,观察组50例加用尤瑞克林、高压氧治疗,对比两组效果。结果两组急性脑梗死患者治疗前NIHSS评分比较差异未见统计学意义(P>0.05),治疗后评分均有下降,但观察组下降更为显著(P<0.05)。治疗前两组MOCA、WMS、MMSE评分差异未见统计学意义(P>0.05),治疗后均升高,观察组升高更为明显(P<0.05)。观察组总有效率为94%,对照组为72%,差异有统计学意义(P<0.05)。对照组未出现明显不良反应,观察组高压氧治疗中,个别患者有头痛、耳内胀痛症状,未做特殊处理,结束治疗后症状消失。结论针对临床收治的急性脑梗死病例,采用尤瑞克林联合高压氧治疗可显著改善神经功能及认知功能,增强临床总有效率,且具有较高安全性,对保障患者生存质量意义显著。

Objective To study the clinical effect of urinary kallidinogenase combined with hyperbaric oxygen therapy on acute cerebral infarction. Methods From February 2014 to February 2016,100 patients with acute cerebral infarction were randomly divided into two groups. Fifty cases in control group received conventional therapy such as anti platelet aggregation,and 50 cases in observation group were treated with urinary kallidinogenase and hyperbaric oxygen therapy.Results NIHSS score of the two groups before treatment had no significant difference（ P 0. 05）,and after the treatment,the score decreased,but the reduction of observation group was more significant（ P 0. 05）. MOCA,WMS,MMSE score of the two groups had no significant difference before treatment（ P 0. 05）,and increased after treatment,which were more significant in the observation group（ P 0. 05）. The total effective rate of observation group was 94%,and 72% in the control group,the difference was significant（ P 0. 05）. There was no significant adverse reactions in control group,and there were symptoms of headache,ear pain,which disappeared after treatment in observation group. Conclusion For clinical treating acute cerebral infarction,the use of urinary kallidinogenase combined with hyperbaric oxygen therapy can significantly improve the nerve function and cognitive function,strengthen the clinical total effective rate,and has high security,to ensure the quality of life.