血栓抽吸联合盐酸替罗非班用于心肌梗死急诊介入治疗中的临床效果

Effect of thrombus suction combined with tirofiban hydrochloride on myocardial infarction interventional treatment

目的分析心肌梗死介入治疗中血栓抽吸联合盐酸替罗非班治疗的效果。方法 2013年12月至2015年4月笔者收集急诊经皮冠状动脉介入(PCI)治疗的急性ST段抬高性心肌梗死(STEMI)64例,冠状动脉造影提示高度血栓负荷。根据治疗方法随机分为观察组(血栓抽吸联合盐酸替罗非班)和对照组(仅行PCI术)。结果 PCI术后,观察组MPG 3级以及TIMI血流3级发生率均高于对照组;随访1年,观察组主要心血管不良时间(MACE)、靶血管血运重建(TVR)及靶病变再次血运重建(TLR)发生率均低于对照组(P均<0.05)。结论血栓抽吸联合盐酸替罗非班能显著改善高度血栓负荷的急性ST段抬高性心肌梗死患者TMPG分级、TIMI血流,改善患者1年生存质量。

Objective To analyze the emergency interventional treatment effect of thrombus suction combined with tirofiban hydrochloride on myocardial infarction. Methods From December 2013 to April 2015,64 patients with acute ST segment elevation myocardial infarction（ STEMI） underwent emergency percutaneous coronary intervention（ PCI） were selected,the coronary anteriongraphy showed coronary arteriography prompt highly thrombus load. According to the treatment,they were randomly divided into observation group（ thrombus suction combined with tirofiban hydrochloride） and control group（ only PCI）. Results After PCI,the incidences of MPG level 3 and TIMI flow level 3 in the observation group were higher than those in the control group. After follow-up of 1 year,the incidences of MACE,TVR and TLR in the observation group were lower than those in the control group（ P 0. 05）. Conclusion Thrombus suction combined with tirofiban hydrochloride can significantly improve the TMPG grading,TIMI flow in high thrombosis load patients with acute ST elevation myocardial infarction,and improve the 1-year survival quality.