老年慢性肾脏病贫血病人血铁调素的水平

Level of hepcidin in elderly patients with chronic kidney disease complicated with anemia

目的观察老年慢性肾脏病(CKD)贫血病人铁调素的表达水平变化。方法随机选择在江苏省老年医院肾内科门诊随访的50例贫血的老年CKD病人及50例无贫血的CKD病人。登记病人的身高、体质量、年龄、性别、合并存在疾病及目前服用药物,留取病人清晨空腹血标本,检测病人红细胞计数(RBC)、血红蛋白(Hb)、红细胞比容(Hct)、超敏C反应蛋白(hs-CRP)、尿素氮(BUN)、血肌酐(Scr)、铁调素等指标并分析铁调素的影响因素。结果老年CKD病人贫血主要在CKD 3期后出现,随年龄的增加,老年CKD病人Hb、RBC、Hct等水平逐渐下降。与无贫血的老年CKD病人比较,CKD贫血病人铁调素水平升高,差异有统计学意义。血清铁调素水平与BUN、Scr呈正相关(r=0.363,0.476),与RBC、Hb、Hct呈负相关(r=-0.472、-0.512、-0.471)。结论老年CKD贫血病人铁调素水平明显升高,可能参与老年CKD病人贫血的调节。

Objective To observe the level of hepcidin in elderly patients with chronic kidney disease（ CKD） complicated with anemia. Methods The levels of serum hepcidin,high sensitivity C reactive protein（ hs-CRP）,the levels of red blood cell（ RBC）,hemoglobin（ Hb）,hematocrit（ Hct）,blood urea nitrogen（ BUN）,serum creatine（ Scr） were measured in 100 elderly patients with CKD（ 50 with anemia,50 without anemia）. Results The levels of Hb,RBC and Hct declined in CKD patients with the increase of age. The level of hepcidin increased significantly in CKD patients with anemia,compared to CKD patients without anemia（ P〈0. 05）. Correlation analysis showed that serum levels of BUN,Scr were positively correlated with hepcidin（ r = 0. 363,0. 476,all P〈0. 05）,while RBC,Hb,Hct were negtively correlated with hepcidin（ r =-0. 472,-0. 512,-0. 471,all P〈0. 05） in the CKD patients suffering from anemia. Conclusions The level of hepcidin increases in CKD patients complicated with anemia,which may take part in the regulation of anemia.