EB 病毒 Rta 蛋白抗体 IgG 在鼻咽癌诊断中的应用及临床意义

Application and clinical significance of EB virus Rta protein antibody IgG in diagnosis of nasopharyngeal carcinoma

目的：对 EB 病毒 Rta 蛋白抗体 IgG 在鼻咽癌诊断中的应用及临床效果进行研究分析。方法选取2015年6月至2016年5月收治的82例鼻咽癌患者作为研究组，80例健康体检人员作为对照组，研究组和对照组均通过酶联免疫吸附试验方法进行血清 Rta-IgG 抗体水平检测，对两组 Rta-IgG 表达水平差异及其与鼻咽癌临床分期（Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期）的关系进行比较分析。结果研究发现，研究组患者 Rta-IgG 抗体表达水平明显高于对照组；并随着鼻咽癌患者疾病的发生而发展，患者的 Rta-IgG 抗体表达水平呈现上升趋势。研究组患者和对照组健康体检人员的检查结果比较差异有统计学意义（P ＜0.05）。结论研究组患者体内血清的 EB 病毒 Rta-IgG 抗体相关表达和鼻咽癌发生和发展有着密切联系，应用 EB 病毒 Rta 蛋白抗体 IgG 对鼻咽癌患者进行诊断具有重要的临床价值。

Objective To study and analyze the application and clinical effect of EB virus Rta protein antibody IgG in diagnosis of nasopharyngeal carcinoma. Methods From June 2015 to May 2016, 82 cases of nasopharyngeal carcinoma were selected as the research group,and another 80 cases of healthy persons were selected as the control group. The level of serum Rta-IgG antibody was detected by enzyme-linked immunosorbent assay,the expression level of Rta-IgG in the two groups and its correlation with the clinical stage of nasopharyngeal carcinoma（stage I,Ⅱ,Ⅲ,IV）were compared and analyzed. Results The expression level of Rta-IgG in the study group was significantly higher than that in the control group. With the development of the disease of nasopharyngeal carcinoma patients,the expression level of Rta-IgG antibody showed an upward trend. There were significant differences in the examination＆nbsp;results between the study group and the control group（P 〈 0. 05）. Conclusions In the study group, the expression of EB virus Rta-IgG antibody in serum is closely correlated with the occurrence and development of nasopharyngeal carcinoma,application of EB virus Rta protein antibody IgG has important clinical value for the diagnosis of nasopharyngeal carcinoma patients.