超声造影技术在肝硬化合并小肝癌早期诊断中的应用价值

Application value of contrast-enhanced ultrasound in the early diagnosis of cirrhosis combined with small hepatocellular carcinoma

目的：探讨采用超声造影技术对肝硬化合并小肝癌进行诊断的临床价值。方法随机选择2014年2月至2016年1月肝硬化合并小肝癌患者75例，对所有患者进行肝脏占位性病变的超声造影检查，观察记录病灶造影增强模型，并对其进行分析。结果75例患者共计检出病灶180个，经超声造影共计确诊72例，诊断灵敏度为96.00％；中-低分化癌患者的增强开始时间和消退开始时间最短，明显短于透明细胞癌和高分化癌患者（P ＜0.05）；中-低分化癌患者的增强达到峰值时间明显短于透明细胞癌和高分化癌患者，差异有统计学意义（ P ＜0.05）。结论肝硬化合并小肝癌的早期诊断对于改善患者预后具有十分积极的意义，通过对此类患者实施超声造影检查，可有效明确疑似恶性病灶，提高肝硬化合并小肝癌的早期诊断准确率。

Objective To investigate the clinical value of contrast-enhanced ultrasound（CEUS） in the early diagnosis of cirrhosis combined with small hepatocellular carcinoma. Methods From February 2014 to January 2016,75 patients with cirrhosis combined with small hepatocellular carcinoma were randomly selected, the hepatic lesions were examined by CUES in all patients, contrast enhancement model of the lesions were recorded and analyzed. Results Among the 75 patients,a total of 180 lesions were detected,and 72 patients were confirmed by CEUS,the diagnosis sensitivity was 96. 00% ;the enhancement start time and regression start time in moderately-poorly differentiated cancer patients were significantly shorter than those in clear cell carcinoma and highly differentiated cancer patients（P 〈 0. 05）;the enhanced to peak time in moderately-poorly differentiated cancer patients was significantly shorter than that in highly-differentiated cancer and clear cell carcinoma patients,the difference was significant（P 〈 0. 05）. Conclusions Early diagnosis of cirrhosis combined with small hepatocellular carcinoma,has a great significance in improving the prognosis of patients,can effectively clear the suspected malignant lesions,improve the early diagnostic accuracy of small hepatocellular carcinoma combined with cirrhosis.